
21 Jan Evolved.Bio
Alireza Shahin, Ph.D., CEO
Ontario, Canada
(Private)
Evolved.Bio is a pre-clinical stage tissue therapeutics company creating the most in vivo-like tissues in a completely scaffold/biomaterial-free way using its proprietary Anchored Cell Sheet Engineering platform. Evolved’s first product is focused on skeletal muscle regeneration in the case of traumatic injury, but partnerships with multiple commercial groups are expanding the pipeline to include hepatic, pancreatic, and cardiac tissues. Scaffold-based solutions have limited efficacy because the exogenous biomaterials do not properly integrate with host tissues, interfere with natural cellular processes, have significant variability, and cause severe immune responses, all impeding regeneration. Evolved solves these issues by creating tissues composed of only properly differentiated cells and the mature, tissue-specific ECM that they produce. This enables Evolved’s tissues to properly engraft with the host tissue and regenerate the target. Evolved’s ultimate goal is to heal every damaged tissue.